NOLA, aren't you glad now you are not invested in BHRT?
Best wishes to you. Enjoy your posts!
The following was someone else's explanation with engraftment:
Migration means the cells moved from the site of injection, to lay down on the bruchs membrane. Engraftment means they stayed there, attached and survived (for how long we dont know yet). You can find plenty of literature to confirm that for you. Combined with the absence of a safety red flag, this means our therapy 100% no ifs ands or buts does what it was intended to do. We don't know, in humans (especially this deteriorated) if it would be sufficient for visual acuity improvement. But we can safely say it would be necessary. We'll know shortly whether vision improved or not. I'm hopeful and expecting it based on what we've read heard and know. Based on decades of animal research though, we know that engraftment is necessary and sufficient to prevent vision loss if patients with AMD and SMD were to be treated earlier. That will come in Phase 3.
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