22 - Just a note to say thank you for your energy and talent in supporting and driving the Thread on Barcelona recently. I'm glad we were able to work together on this, our latest project, to bring the latest news and information to everyone. It shows in the numbers what a powerful place 22's House is when rocking and that's a testament to your Direction. Thank you my friend for your kind words. Cheers

Hi John, I have been having million dollar dreams this week, finding it, winning it and having it come up on the ACT shares, whats going on? And my little wolf pup is now grown into a young wolf adult, he is ready. Maybe something big is coming our way at last....

Noel

PS your email box is still full and I can't email you

Hey John, how you doing, things have been very very quiet of late, I hope your chin is still up and you are still smiling. Just a quick hello and hope all is fine for you.
Oh yeah, your inbox says it is full and you need to empty it so I can send you an email

pacman

John, I just sent this to Eddie, "between you and twenty2, thanks, I feel safe when I know you guys have my back, you are a truly great guy and I am honoured to call you my friend."

Thanks for your friendship and support, what you have done in friendship is beyond the calling, "I am honoured to call you my friend", keep up the good work mate

Noel

Well just look at my Badge, payback can be fun too

Thanks mate, never would have done it without that stick on my back, looks pretty cool too

John, what are you going to do with your 22 forum now? What thread topics?

And yes, I am as guilty as sin, but what a hoot

Hi twnty2,

Thanks for the likes. Here's a couple of comments re: the DMD subject Sue and the lack of visible engraftment.

I wonder if you could note to Dr. Lanza the following:

1) Perhaps one low dose is not enough for engraftment. Repeated and/or larger doses could be required.

2) Perhaps another chemical for the "B" membrane or even preoperative nutrition/vitamin supplements would encourage more engraftment. Or as others have stated, using a younger subject with less severe MD.

The point is, not to see the initial DMD subjects as all or none RPE procedures.

Good regards,

Art K

Hi Twenty2,

Not convinced Sue is seeing better if she has eyes on you but oh well
Seriously, can you check out the thread pacman started about why Sue seeing better. I posted that perhaps you could speak with Lanza on this. It's very important IMO since the world will not just accept "she see's better, why worry about why". Thanks for all you do for ACTC. You rock.

Personally, I think trying to use Sue as the leading argument for why this therapy is working is not a good choice...too easy to dismiss the result.

Thanks and hopefully you understand the objectivity that I'm trying to convey here... I'm obviously hopeful that the SMD patient's results are going to be the standard result when we have more patients to compare.

Cheers

Hort

I suppose it is possible that the cells trans-differentiated into another cell type or migrated into another region of the eye, but I would imagine that the OCT images would reveal that. Perhaps the lifetime of the cells was too short to be visualized but did have a therapeutic effect.

Obviously the SMD patient is the better case to consider, but for privacy reasons she is not in the limelight.